Cedars-Sinai Medical Center
Title: A REVIEW OF THE DIFEERENT PATHWAYS THAT LEAD TO NEURODEGNERATION IN THE PATHOPHYSIOLOGY OF DEMENTIA.
LUIS ANGEL FRANCISCO SORROZA LOPEZ completed medical school at age 26 at Universidad Regional del Sureste, Medical School, in Oaxaca, Mexico, and master studies in Clinical Pharmacology at La Salle University, Mexico, School of Chemical Science. He received first prize in the category of master level Health Sciences (2015) from this current University, and has been speaker at the 5th International Congress of Dementia and Alzheimer in London (2016), and published the correspondent article
Dementia is growing as a major cause of disability in the world due to neurodegeneration, it is considered a syndrome under which several pathologies are included with the hallmark of cognitive deficits and progressive loss of ability in the performance of regular activities of daily life which eventually jeopardize the self-sufficiency of the person suffering the condition; therefore representing a burden for family carers and health systems all over the world. Aging has been considered the strongest risk factor, but it is not a normal part of it, and the incidence is increasing also in younger population. The accumulation of beta-amyloid, hyperphosphorilation of TAU and oxidative stress have been a hardcore of the neurodegenerative process, and incredible advances have been done in the research of the pathogenesis lately. We have researched the database of PubMed, Cochrane, Medline, Science-direct, and EBSCO, to collect evidence of 325 references on the following subjects: dementia, Alzheimer´s disease, pathophysiology, epidemiology, systematic reviews, diabetes, insuline dysregulation, blood brain barrier, genetics and epigenetics. We have made a review to analyze the different theories focusing in the multifactorial interaction in the pathophysiology of the condition. Nevertheless it is still necessary to pursue further research, which in the near future will offer a more detailed understanding of the process, and probably will reveal specific fields to provide effective treatment, or preventive strategies in very early stages of the disease, probably isolating certain conditions from the common tree of the syndrome, but with better overall results.