Speaker Biography

Shouhartha Choudhury

Assam University India

Title: Genomics of OLIG family of bHLH transcription factor

Shouhartha Choudhury
Biography:

Shouhartha Choudhury has completed his B.Tech and M.Tech in Bioinformatics from India and now pursuing integrated pre-Ph.D. research in School of Life Sciences, Department of Biotechnology, Assam University, Silchar-788011

 

Abstract:

The present study investigated OLIG (Oligodendrocyte lineage gene) induce differentiation of neural progenitors and express oligodendrocyte and putative immature progenitor cells in the adult central nervous system. The murine bHLH transcription factors OLIG1 and OLIG2 essential for oligodendrocyte development found to chromosome 21. OLIG1 participate oligodendrogenesis and OLIG2 express in immature neuron and multipotential glia in the embryonic olfactory neurons. OLIG2 a marker of diffuse glioma and faithfully restricted to the normal oligodendroglia in human brain. In rodents, expression heterogeneity demonstrated OLIG1 and OLIG2 characteristics of various glial tumors. OLIG3 is a third gene of OLIG family detected in the dorsal neural tube in midbrain, hindbrain, and spinal cord. In this study, we curated literature-derived information of the OLIG family and their specific bHLH domain in genomic data. We accumulate eukaryotic organism i.e. Homo sapiens and Mus musculus and performed comparative and functional analysis. The complete bHLH transcription factor data analysis suggested number of OLIG genes and their domain, motifs, phylogeny, chromosome location and gene expression. In this study, we performed bioinformatics and computational techniques to the current knowledge of OLIG family of bHLH transcription factor.