4th Annual Conference on
Brain Disorders, Neurology and Therapeutics

Biography:

Dr Ahmed Allam has his expertise in the field of neurogenesis and neurobehaviors especially in the newborns. Many of his publications and works focus on the damage which produced in the brain regions due to perinatally toxins exposure during development and how to repair this damage and reduce its hazards and how mothers could be avoided from these teratogenic factors even tough toxins or manners. Also, Dr Allam has some expertise in the following area Biochemistry, Genetics and Molecular Biology, Biological Sciences, Neuroscience, Medicine, Chemistry, Environmental Science, Pharmacology, Toxicology and Pharmaceutics Immunology.

Abstract:

The present study aimed to elucidate the abnormalities in the development of rat brains and behaviours after drinking desalinated seawater prenatally. Three types of drinking water were employed as an experimental probe (bottled water, filtered desalinated seawater and tap desalinated seawater) to investigate neurobehavioral and morphological changes in the development of pup rats. Female rats from each group were administered water from their birth until gestation and lactation. The 1st and 2nd generation pups were divided into three groups: Group C, mothers and pups administered with bottled drinking water (the control group); Group F, mothers and pups administered with filtered drinking water; Group T, mothers and pups administered with unfiltered desalinated seawater (tap water). Morphological changes (CNS aberration) and neurobehavioral changes were studied. The aberrations recorded in the brain regions (cerebellum, cerebrum, medulla oblongata) and spinal cord of rat’s newborns from groups T and F may be due to oxidative stress in these tissues such as reduced glutathione, lipid peroxidation, peroxidase and super oxide dismutase. In conclusion, drinking desalinated seawater for a long time may cause teratogenic effects in the development of New-born rats.